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phenobarbital will reduce the extent or result of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.phenobarbital will lessen the level or result of diclofenac by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Unfamiliar.DailyMed will deliver notification of updates and additions